TY - JOUR T1 - Extensive pyoderma gangrenosum-like lesions revealing a case of hyperzincemia and hypercalprotectinemia: when to suspect it? JO - Anais Brasileiros de Dermatologia T2 - AU - Resende,Ludimila Oliveira AU - Jorge,Marilia Formentini Scotton AU - Schmitt,Juliano Vilaverde SN - 03650596 M3 - 10.1016/j.abd.2018.12.001 DO - 10.1016/j.abd.2018.12.001 UR - http://www.anaisdedermatologia.org.br/en-extensive-pyoderma-gangrenosum-like-lesions-revealing-articulo-S0365059619300698 AB - Hyperzincemia and hypercalprotectinemia is a rare inflammatory disease caused by a mutation in the PSTPIP1 gene, with a dysregulation of calprotectin metabolism. Calprotectin is a zinc-binding protein with antimicrobial properties and pro-inflammatory action. The authors report the case of a 20 year-old girl with cutaneous ulcers comparable with pyoderma gangrenosum, growth failure and chronic anemia, who was given the diagnosis of hyperzincemia and hypercalprotectinemia. Measurement of serum zinc and calprotectin concentrations are indicated in these cases. ER -