TY - JOUR T1 - Enhanced serum interferon-lambda 1/interleukin-29 levels in patients with psoriasis vulgaris JO - Anais Brasileiros de Dermatologia T2 - AU - Fu,Li-xin AU - Chen,Tao AU - Guo,Zai-Pei AU - Cao,Na AU - Zhang,Li-Wen AU - Zhou,Pei-Mei SN - 03650596 M3 - 10.1016/j.abd.2020.11.007 DO - 10.1016/j.abd.2020.11.007 UR - http://www.anaisdedermatologia.org.br/en-enhanced-serum-interferon-lambda-1-interleukin-29-levels-articulo-S0365059621001240 AB - BackgroundInterferon (IFN)-λ1, also named Interleukin (IL)-29, is a new member of the Type III IFN or IFN-λ family. IL-29 plays an important role in the pathogenesis of many types of autoimmune and inflammatory diseases. ObjectiveTo study the role of IL-29 in the pathogenesis of psoriasis vulgaris. MethodsThe authors detected the serum levels of IL-29 in forty-one patients with psoriasis vulgaris, twenty-three patients with atopic dermatitis and thirty-eight age and gender-matched controls by sandwich Enzyme-Linked Immunosorbent Assay (ELISA). The effects of IL-29 on the expression of cytokines, such as IL-6, IL-17, IL-8, IL-4, IL10, Interferon (IFN-γ) and Tumor Necrosis Factor-α (TNF-α), in PBMCs and HaCat cells were determined by real-time quantitative PCR. ResultsOur data indicated that serum IL-29 levels were significantly elevated in patients with psoriasis vulgaris when compared with atopic dermatitis patients and the control group. Moreover, Serum levels of IL-29 were closely associated with the severity of psoriasis vulgaris. Furthermore, IL-29 up-regulated the mRNA expression levels of IL-6, IL-17 and TNF-α in PBMCs from psoriasis vulgaris patients. In addition, IL-29 enhanced the IL-6 and IL-8 expression from the HaCat cells. ConclusionThis study provides the first observations on the association of IL-29 and psoriasis vulgaris and showed elevated IL-29 serum levels. The authors suggest that IL-29 may play a role in the pathogenesis of psoriasis vulgaris. ER -