Pathology of peliosis
Introduction
Peliosis is a comparatively rare pathological entity characterized by the presence of multiple blood-filled cavities within parenchymatous organs. The word “pelios” is greek, meaning blackish–bluish with sugillation, and was first used by Wagner in 1861 to describe the gross appearance of the lesions on cut surfaces of the liver [1]. The diagnosis of peliosis may be occasionally established at autopsy by the unique gross appearance of multiple cyst-like, blood-filled cavities on cut-surfaces of the affected organ, but usually the disease is a histological diagnosis [2], [3], [4], [5], [6], [7]. Peliosis has been related to several underlying debilitating illnesses or medications, and different theories have been proposed concerning the pathogenesis of this unique disorder over the years. While some investigators favour congenital malformation of vessels or microcirculatory disturbances manifesting under altered local intravascular pressure conditions as responsible for the development of the disease [4], [8], [9], [10], others believe that an acquired vascular disorder triggered by toxic noxae may play a key role in the pathogenesis [11], [12]. However, none of the chronic or toxic conditions previously described in association with peliosis or the pathogenetic mechanisms they may induce can satisfactorily explain the pathological findings in all cases and organs involved, respectively, and the morphological data obtained by different investigators suggest that there is more than one path of formal pathogenesis to the onset and maintenance of peliosis.
The classical pathoanatomical concept is based upon the opinion that peliosis exclusively develops in organs belonging to the mononuclear phagocytic system (MPS, formerly known as the “reticuloendothelial system”) and therefore only affects the liver, spleen, bone marrow, and lymph nodes [12], [13]. However, a paucity of studies indicates that other organs such as lungs, gastrointestinal tract, parathyroid glands, pituitary, pancreas, adrenals, and kidneys may be affected by the disorder too [14], [15], [16], [17], [18].
Apart from the pathology of peliosis of the liver, the vast majority of patho-anatomical textbooks and manuals devote no attention to the distinctive morphological features of the disease. This review summarizes the pathological features of peliosis, pointing out towards the forensic pathological significance of the disease. It was neither the objective of the present work to give an extensive overview on the available literature on peliosis nor to discuss clinical aspects of the disease. For the latter, it is referred to the comprehensive clinical literature related to peliosis.
Section snippets
Peliosis of the liver
In 1916, Schoenlank introduced the term peliosis hepatis into the literature describing the case of a 33-year-old woman who died of miliary tuberculosis [19]. In his case report, nearly 90 years ago, Schoenlank described the gross pathology of the liver as follows: “Underneath Glisson’s capsule, in a diffuse pattern, bluish–reddish–blackish spots that have a circular appearance and measure up to 0.15 cm are visible. On cut surfaces, these spots come out into the open as bleedings (…). One cannot
Peliosis of the spleen
The first well-documented autopsy case of peliosis of the spleen goes back to 1866 when Cohnheim described the case of a 27-year-old man who died suddenly as an in-patient of a psychiatric ward [36]. Autopsy revealed approximately 1 l of fluid and clotted blood within the abdominal cavity. The source of bleeding was found to be a rupture on the surface of the spleen. Cross-sections of the spleen revealed multiple cystic spaces reaching up to several centimeters in diameter that were filled with
Peliosis in other organs
In 1961, Kent and Thompson described the pathological features of two autopsy cases of peliosis hepatis with additional peliotic involvement of the spleen, lymph nodes, and bone marrow in one of their cases, thereby, from these author’s point of view, indicating towards a general (so far undetermined) stimulus affecting solely organs belonging to the MPS [12]. This report was the basis for the still prevailing classical pathoanatomical concept that peliosis exclusively develops in organs
Forensic pathological significance of peliosis
When detecting the aforementioned characteristic features at gross examination or histological examination, respectively, the pathologist should bear peliosis as a possible diagnosis in mind. Of course, peliosis of parenchymatous organs may be a pure incidental finding at autopsy or under the microscope, respectively, that has neither any relation between cause and effect of the underlying disease nor any causal connection with or pathological relevance to the cause of death. Nevertheless,
References (47)
- et al.
Peliosis lienalis: uncommon cause of rupture of the spleen
Pathol. Res. Pract.
(1992) Letter to the case
Pathol. Res. Pract.
(1992)Immunohistochemical localization of collagen type III and type IV, laminin, tenascin and α-smooth muscle actin (αSMA) in the human liver in peliosis
Pathol. Res. Pract.
(2002)- et al.
Hepatic rupture caused by peliosis hepatis
Pediatr. Surg.
(2001) - et al.
Peliosis hepatis with initial presentation as acute hepatic failure and intraperitoneal hemorrhage in children
J. Hepatol.
(1999) - et al.
Peliosis of the spleen with rupture
Hum. Pathol.
(1982) Peliosis: a morphologic curiosity becomes an iatrogenic problem
Hum. Pathol.
(1978)Ein Fall von Blutcysten in der Leber
Arch. Heilkunde
(1861)- et al.
Peliosis hepatis. Twelve cases associated with oral androgen therapy
Arch. Pathol. Lab. Med.
(1977) - et al.
Peliosis of the spleen. Report of a case and review of the literature
Arch. Pathol. Lab. Med.
(1982)
Peliosis of the spleen
Am. J. Clin. Pathol.
Peliosis hepatis in the acquired immunodeficiency syndrome
Arch. Pathol. Lab. Med.
Peliosis of the spleen: an immune-complex disease?
Histopathology
Peliosis of the spleen. Report of a case associated with chronic myelomonocytic leukemia, presenting with spontaneous splenic rupture
Am. J. Surg. Pathol.
Peliosis hepatis
Am. J. Pathol.
Peliosis hepatis. Report of three cases, with discussion of pathogenesis
Arch. Pathol.
Peliosis hepatis. Involvement of reticuloendothelial system
Arch. Pathol.
Peliosis hepatis. An unusual case involving multiple organs
Acta Pathol. Jpn.
Pulmonary peliosis
Arch. Pathol. Lab. Med.
Parathyroid peliosis: report of a case and review of the literature
Pediatr. Pathol.
Microscopic peliosis of pancreatic islets in a woman with MEN-1 syndrome
Arch. Pathol. Lab. Med.
Cushing’s syndrome from an ectopic pituitary adenoma with peliosis: a histological, immunohistochemical, and ultrastructural study and review of the literature
Endocr. Pathol.
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