ReportsCharacteristics of genetic epidemiology and genetic models for vitiligo☆
Section snippets
Study population
All of the patients included in this report were outpatients who were referred to a collaborative network established to study genetic skin diseases. The network consisted of dermatologists working for hospitals located in Hefei, Xiangfan City, Xi'an, and Beijing, China. In all, 3775 patients (probands) were interviewed and given the diagnosis of vitiligo from July to December 2002. The race of all probands was Chinese Han, the major ethnic group constituting more than 90% of the Chinese
Proband characteristics
Of 2247 probands, 583 (25.9%) individuals had focal, 1035 (46.1%) had vulgaris, 66 (2.9%) had universal, 243 (10.8%) had acrofacial, and 320 (14.2%) had segmental vitiligo. For all types of vitiligo, the interval of onset ages with the highest prevalence was 10 to 14 years (Table I). No statistically significant difference was found in the distributions of ages of onset between male and female probands (Mann-Whitney test, P = 0.243), which was consistent with the findings of Majumder et al.7 In
Discussion
Vitiligo, first noted in approximately 1500 bc, afflicts all populations around the world with diverse prevalence rates among different geographic regions and ethnic groups ranging from 0.1% to 2%.3., 6. Little is known about the genetic nature of vitiligo, although there have been many studies on familial clustering4., 5., 8., 9. and susceptibility genes.12., 13., 14., 15., 16., 17., 18. Previous studies have investigated vitiligo as a whole, ignoring the clinical classifications of vitiligo.
Acknowledgements
We express our gratitude to Drs Weihua Jia, Scott Venners, Xin Xu, Debin Wang, and Jiahu Hao for their valuable comments, suggestions, assistance in statistical analyses, and editing of the manuscript. We thank Dr Tianwen Gao of the Department of Dermatology, Xijing Hospital of Fourth Military Medical University, Shanxi, China, and Dr Shi Lian of the Department of Dermatology, Xuanwu Hospital of the Capital Medical University, Beijing, China, for their help in collecting clinical data.
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Supported by grant 2001AA227031 from Chinese High Tec Programs (863). Some of the results of this study were obtained by using the SAGE software, which is supported by a US Public Health Service Resource Grant (RR03655) from the National Center for Research Resources.
Conflicts of interest: None identified.