Original articleFrontal fibrosing alopecia: A multicenter review of 355 patients
Section snippets
Methods
This multicenter study included 12 Spanish centers applying the methodology as described below at all centers. A retrospective observational and analytic review was designed including patients given the diagnosis of FFA from 1994 to 2013. Diagnosis was made histologically or based on the typical clinical presentation (irregular recession of the frontotemporal and preauricular hairline with eyebrow loss) and characteristic dermoscopic findings. All doubtful cases including men and premenopausal
Results
A total of 355 patients (343 women [49 premenopausal] and 12 men) with a mean age of 61 years (range 23-86) were included in the study. All were Caucasian except for 3 black-skinned women (0.9%) and 2 gypsy women (0.5%). The mean age of menopause was 49 years (range 23-60). Early menopause (≤45 years) was detected in 49 patients (14%), with a surgical cause in 31 of them (9%). A total of 46 patients (13%) underwent hysterectomy (31 premenopausal and 15 postmenopausal). The mean age of onset of
Discussion
FFA is a primary scarring alopecia and is considered to be a variant of LPP with a characteristic clinical pattern of progressive frontotemporal hairline recession and eyebrow loss. It occurs mainly in postmenopausal women,1, 20 although premenopausal women2, 11, 12, 17, 21, 22 and men23, 24, 25 may also be affected. The mean age of onset in our study is similar to previous reports (Table III).8, 11, 16 The youngest patient of our study was a 23-year-old man, which is, to our knowledge, the
References (40)
- et al.
Postmenopausal frontal fibrosing alopecia: a frontal variant of lichen planopilaris
J Am Acad Dermatol
(1997) - et al.
Diagnostic and therapeutic assessment of frontal fibrosing alopecia
Actas Dermosifiliogr
(2007) - et al.
Primary cicatricial alopecia: histopathologic findings do not distinguish clinical variants
J Am Acad Dermatol
(2005) - et al.
Expanding the spectrum of frontal fibrosing alopecia: a unifying concept
J Am Acad Dermatol
(2010) - et al.
Frontal fibrosing alopecia: a retrospective review of 19 patients seen at Duke University
J Am Acad Dermatol
(2013) - et al.
Frontal fibrosing alopecia: a review of 60 cases
J Am Acad Dermatol
(2012) - et al.
Frontal fibrosing alopecia in postmenopausal women
J Am Acad Dermatol
(2005) - et al.
Treatment of postmenopausal frontal fibrosing alopecia with oral dutasteride
J Am Acad Dermatol
(2009) - et al.
Hydroxychloroquine and lichen planopilaris: efficacy and introduction of Lichen Planopilaris Activity Index scoring system
J Am Acad Dermatol
(2010) - et al.
Study of frontal hairline patterns in Spanish Caucasian women
Actas Dermosifiliogr
(2013)
Frontal fibrosing alopecia presenting with components of Piccardi-Lassueur-Graham-Little syndrome
J Am Acad Dermatol
Prevalencia del hipotiroidismo tratado en la población adulta
Aten Primaria
Frontal fibrosing alopecia: dermoscopic features
Actas Dermosifiliogr
Postmenopausal frontal fibrosing alopecia: scarring alopecia in a pattern distribution
Arch Dermatol
Postmenopausal frontal fibrosing alopecia
Br J Dermatol
Postmenopausal frontal fibrosing alopecia: 20 cases
Ann Dermatol Venereol
Frontal fibrosing alopecia: a survey in 16 patients
J Eur Acad Dermatol Venereol
Frontal fibrosing alopecia: clinical presentations and prognosis
Br J Dermatol
The follicular triad: a pathological clue to the diagnosis of early frontal fibrosing alopecia
Br J Dermatol
Frontal fibrosing alopecia: treatment with oral dutasteride and topical pimecrolimus
J Eur Acad Dermatol Venereol
Cited by (0)
Funding sources: None.
Conflicts of interest: None declared.