Original articleThe role of in vivo confocal microscopy in the diagnosis of eyelid margin tumors: 47 cases
Section snippets
Methods
A total of 45 consecutive patients (19 female, 36 male; average age 64 years, range 13-94 years) presenting with a total of 47 eyelid margin tumor lesions were recruited at the Department of Dermatology, University Hospital of Saint-Étienne, France, between January 2011 and June 2013. Clinical and IVCM diagnoses were established by a team of 3 dermatologists (E. C., J. L. P., B. L.) and 2 ophthalmologists (D. G., M. E.).
IVCM examination was carried out with a handheld microscope for skin
Results
IVCM features of the tumor-free mucosa varied according to the area of the eyelid margin. Three main different areas were identified: the cutaneous outer part, the mucous intermediate part, and the inner tarsal conjunctiva. Although the first resembled normal-appearing skin, the mucous intermediate part was characterized by: (1) the absence of stratum corneum and stratum granulosum, (2) the absence of papillae, and (3) prominent chorion capillaries. The same features were evident in the tarsal
Discussion
Our study showed that skin-specific handheld IVCM can be a new tool for the noninvasive diagnosis of eyelid margin tumors. Two IVCMs are currently available to explore the eye surface: a 4-slit scanning confocal microscope (Confoscan, Nidek, Gamagori, Japan) and a laser-scanning confocal microscope (Heidelberg Retina Tomograph,5, 6 Heidelberg Engineering GmbH, Heidelberg, Germany). Because of their limited ease of handling, both these microscopes are mostly used to view the cornea and more
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Funding sources: None.
Reprints not available from the authors.
Conflicts of interest: None declared.