DermatopathologyDiffuse dermal angiomatosis of the breast: Clinicopathologic study of 5 patients
Section snippets
Methods
A 4-mm punch biopsy specimen of skin was obtained from an area of reticular erythema from 4 patients; the specimen from 1 patient (patient 2) was obtained elsewhere and reviewed at our institution. The specimens obtained internally were processed for routine histology. Immunohistochemical staining for CD31 was performed on specimens from 3 patients (patients 1, 4, and 5). Immunohistochemical staining for CD34 was performed on 1 specimen (patient 1). In situ hybridization for human herpesvirus
Results
The clinical characteristics and course of the 5 patients are summarized in Table I. Biopsy specimens were obtained from all patients. The findings from all patients were similar. There was diffuse proliferation of benign endothelial cells between collagen bundles in the reticular dermis, confirming DDA in all patients.
Discussion
DDA is a rare variant of reactive cutaneous angioendotheliomatosis characterized by erythematous to violaceous indurated and ulcerated plaques.3 Few cases have been reported. Affected persons are primarily female, with the most common site being the lower extremities (thighs), abdomen,1, 8 and forearm.12 Breast involvement has been thought rare; however, our review of the literature identified breast involvement in 5 of 14 previously reported cases.2, 7, 8, 10, 11 DDA is usually bilateral, most
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Funding sources: None.
Conflicts of interest: None declared.