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Lack of specificity of cytokeratin-15 loss in scarring alopecias

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Cited by (3)

  • Histologic and clinical cross-sectional study of chronic hair loss in patients with cutaneous chronic graft-versus-host disease

    2019, Journal of the American Academy of Dermatology
    Citation Excerpt :

    All scalp biopsy specimens, furthermore, displayed a robust expression of CK15. Although lacking specificity, CK15 remains the best marker for bulge stem cells and is accordingly lost in many scarring alopecias but preserved in nonscarring forms.24,25 All specimens in this study showed strong CK15 expression, and therefore it is suggested that the hair follicle bulge stem cells are maintained in cGVHD patients with both patterns of alopecia despite the perifollicular fibrosis observed in patients with sclerotic alopecia.

  • Immunostaining study of cytokeratins in human hair follicle development

    2020, Anais Brasileiros de Dermatologia
    Citation Excerpt :

    Diseases such as hypotrichosis and monilethrix have already been linked to specific mutations of some CKs.9–11 Other diseases that may affect the hair follicle as lichen planus pilaris show an altered pattern in the expression of certain CKs that could be used as early markers for this disease.12,13 Thus, CKs may be targets for drug development and diagnostic methods that may assist in the early diagnosis and treatment of hair follicle diseases.

Funding sources: None.

Conflicts of interest: None declared.

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