Prevalence of gastrointestinal comorbidities in rosacea: Comparison of subantimicrobial, modified release doxycycline versus conventional release doxycycline

doi:10.1016/j.jaad.2017.08.027

Journal of the American Academy of Dermatology

Volume 78, Issue 2, February 2018, Pages 417-419

https://doi.org/10.1016/j.jaad.2017.08.027 Get rights and content

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References (4)

B. Rainer et al.
Rosacea is associated with chronic systemic diseases in a skin severity-dependent manner: results of a case-control study
J Am Acad Dermatol
(2015)
J.F. Fowler
Anti-inflammatory dose doxycycline for the treatment of rosacea
Exp Rev Dermatol
(2007)

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Cited by (4)

Consensus on the therapeutic management of rosacea – Brazilian Society of Dermatology
2020, Anais Brasileiros de Dermatologia
Citation Excerpt :
They concluded that patients with rosacea should be alerted to possible CV events, especially in relation to arterial hypertension, dyslipidemia, and coronary artery disease.226 More recently, in addition to CV diseases, other disorders have been described as associated with rosacea: neurodegenerative diseases (Parkinson's disease, multiple sclerosis, Alzheimer), neurological disorders (migraine, glioma), psychiatric disorders (depression, anxiety, obsessive-compulsive disorder, social phobia, stress), intestinal disease (Crohn's disease, ulcerative colitis, celiac disease, dysbiosis, H. pylori infection, small intestinal bacterial overgrowth), oncological diseases (thyroid, breast and liver cancer, non-melanoma skin tumors), and autoimmune diseases (diabetes mellitus, rheumatoid arthritis, multiple sclerosis, frontal fibrosing alopecia), among others.224,224–242 In an attempt to explain the coexistence of these systemic diseases with rosacea, studies have been designed to search for similar elements, such as the sharing of genetic and environmental factors, or of immunological and cellular characteristics.
Rosacea is a chronic inflammatory disease of the skin, relatively more frequent in women over 30 with a low phototype and proven genetic predisposition. Although its etiology is unknown and possibly multifactorial, the immunological abnormality, associated with neurovascular dysregulation and triggering factors, are important elements in its pathophysiology, which lead to the main changes of inflammation, vasodilation, and angiogenesis that are responsible for the clinical manifestations. Despite the lack of cure, numerous therapeutic options are available for the different clinical presentations of the disease, with satisfactory responses.
To reach a consensus, with recommendations from experts, on the therapeutic management of rosacea suitable to the Brazilian setting.
The study was conducted by five specialized dermatologists from university centers, representatives of the different Brazilian regions, with experience in rosacea, who were appointed by the Brazilian Society of Dermatology. Based on the adapted DELPHI methodology, the experts contributed through an updated bibliographic review of the scientific evidence, combined with personal experiences.
The group of experts reached a consensus on the relevant aspects in the therapeutic management of rosacea, providing information on epidemiology, pathophysiology, triggering factors, clinical condition, classification, quality of life, and comorbidities. Consensus was defined as approval by at least 90% of the panel.
Despite the impossibility of cure, there are several therapeutic alternatives specific to each patient that provide excellent results, with chances of total improvement and long periods of remission, promoting a positive impact on quality of life. This consensus provides detailed guidance for clinical practice and therapeutic decisions in rosacea.
Effective Treatment of Inflammatory Lesions of Rosacea with Subantibiotic Dose Doxycycline Irrespective of Patient Weight or Baseline Lesion Count Severity
2022, Journal of Clinical and Aesthetic Dermatology
Ocular manifestations of rosacea: A clinical review
2021, Clinical and Experimental Ophthalmology
The Use of Oral Antibiotics in the Management of Rosacea
2019, Journal of Drugs in Dermatology

: Access to the Humana Database, as well as data collection for this study, was supported by Drs Rueda and Kendall, who were employed by Galderma Laboratories, L.P.

: Drs Rueda and Kendall were employed by Galderma Laboratories, L.P., at the time the paper was written. Dr Kang is on the advisory board for Galderma Laboratories, L.P.

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Research letterPrevalence of gastrointestinal comorbidities in rosacea: Comparison of subantimicrobial, modified release doxycycline versus conventional release doxycycline

First page preview

J Am Acad Dermatol

Anti-inflammatory dose doxycycline for the treatment of rosacea

Exp Rev Dermatol

Research letter
Prevalence of gastrointestinal comorbidities in rosacea: Comparison of subantimicrobial, modified release doxycycline versus conventional release doxycycline