Continuing medical educationLichen planus and lichenoid dermatoses: Clinical overview and molecular basis
Section snippets
Cutaneous lichen planus
Key points Cutaneous lichen planus represents a relatively uncommon dermatosis, affecting <1% of the population Consisting of polygonal, pruritic, planar papules or plaques, lichen planus is a heterogeneous papulosquamous eruption of variable morphologic manifestation but a consistent histologic phenotype The etiology of lichen planus remains elusive, although immune dysregulation, infectious, environmental, and genetic factors may play a role in disease pathobiology
Morphologic variants of cutaneous lichen planus
Key points Being morphologically heterogeneous, lichen planus may be hyperkeratotic, annular, bullous, pigmented, or atrophic Lichenoid variants are plentiful and comprise lichenoid drug eruption, lichen planus–like keratosis, lichen nitidus, lichen sclerosus, and lichen striatus Overlap syndromes refer to lichen planus coexisting with a distinct second clinical entity
Cutaneous LP does not always manifest in a classic presentation, because there is an array of LP variants that possess distinct clinical
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Dr Tziotzios and Mr Lee contributed equally to this article.
Funding sources: None.
Conflicts of interest: None disclosed.
Date of release: November 2018
Expiration date: November 2021