Elsevier

Microbes and Infection

Volume 12, Issues 14–15, December 2010, Pages 1085-1090
Microbes and Infection

Review
Does inflammatory acne result from imbalance in the keratinocyte innate immune response?

https://doi.org/10.1016/j.micinf.2010.07.015Get rights and content
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Abstract

Acne is a multifactorial chronic disease affecting around 80% of teenage population. The pathogenesis of acne involves inflammatory reactions and colonization by the Propionibacterium acnes (P. acnes) strain. P. acnes stimulates the keratinocytes involved in the innate immune response, the intensity of which could be influenced either by bacterial intrinsic factors or by endogenous factors of the host.

Keywords

Propionibacterium acnes
Inflammation
Oxidative stress
Innate immunity
Skin

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1

These authors contributed equally to this work.