Sebaceous Neoplasms
Section snippets
Overview
True sebaceous neoplasms (sebaceous adenoma, sebaceoma, and sebaceous carcinoma) are rare skin tumors, in contrast with sebaceous gland hyperplasia, which is encountered frequently in the general population, especially in sun-exposed skin.1, 2, 3 Sebaceous tumors may occur at any age during adulthood, but usually they affect elderly people. Clinically, sebaceous tumors are often mistaken for more common skin tumors, such as basal cell carcinoma and squamous cell carcinoma, and consequently the
Summary
The recognition of tumors with sebaceous differentiation is important, because all sebaceous tumors are potential markers of MTS and require screening for this syndrome. IHC is of limited use to identify sebaceous differentiation in tumors mainly composed of immature sebocytes.
The histologic distinction between sebaceous adenoma and sebaceous hyperplasia can be difficult, which is a dilemma because sebaceous hyperplasia is not associated with MTS, whereas sebaceous adenoma is the most common
References (74)
- et al.
Sebaceous neoplasia and Torre-Muir syndrome
Curr Diagn Pathol
(2007) - et al.
Circumscribed sebaceous neoplasms: a morphological, immunohistochemical and molecular analysis
Pathology
(2016) - et al.
Clinicopathological study of 47 cases of sebaceoma
Ann Dermatol Venereol
(2016) - et al.
Unusual patterns of cutaneous sebaceous neoplasms
Diagn Histopathol
(2010) - et al.
MSH-6: extending the reliability of immunohistochemistry as a screening tool in Muir-Torre syndrome
Mod Pathol
(2008) - et al.
Sebaceous neoplasms and the immunoprofile of mismatch-repair proteins as a screening target for syndromic cases
Pathol Res Pract
(2015) - et al.
Muir-Torre syndrome (MTS): an update and approach to diagnosis and management
J Am Acad Dermatol
(2016) - et al.
Interobserver variability in the diagnosis of circumscribed sebaceous neoplasms of the skin
Pathology
(2013) - et al.
Sebaceous carcinoma
J Am Acad Dermatol
(1995) - et al.
Sebaceous carcinoma of the eyelids: personal experience with 60 cases
Ophthalmology
(2004)
Sebaceous carcinoma of the ocular adnexa: a clinicopathologic study of 104 cases, with five-year follow-up data
Hum Pathol
World Health Organization classification of tumours. Pathology and genetics of skin tumours
Dermoscopy of sebaceous hyperplasia
Arch Dermatol
Sebaceous gland hyperplasia and senile comedones: a prevalence study in elderly hospitalized patients
Br J Dermatol
Cutaneous sebaceous neoplasms
Cancer
Sebaceous neoplasms in Muir-Torre syndrome
Am J Dermatopathol
Sebaceous carcinoma: review of the literature
Dermatol Surg
Human sebaceous tumours harbor inactivating mutations in LEF1
Nat Med
A common human skin tumour is caused by activating mutations in beta-catenin
Nat Genet
Molecular basis of HNPCC: mutations of MMR genes
Hum Mutat
Next-generation sequencing identifies high frequency of mutations in potentially clinically actionable genes in sebaceous carcinoma
J Pathol
Distinct pathways in the pathogenesis of sebaceous carcinomas implicated by differentially expressed microRNAs
JAMA Ophthalmol
Increased gene copy number of HER2 and concordant protein overexpression found in a subset of eyelid sebaceous gland carcinoma indicate HER2 as a potential therapeutic target
J Cancer Res Oncol
TERT promotor mutations in periocular carcinomas: implications of ultraviolet light in pathogenesis
Br J Ophthalmol
Nevus sebaceus: a mosaic RASopathy
Clin Exp Dermatol
Sebaceous carcinoma arising in nevus sebaceus of Jadassohn: a clinicopathological study of five cases
Am J Dermatopathol
Role of immunohistochemistry in the diagnosis of sebaceous carcinoma: a clinicopathologic and immunohistochemical study
Am J Dermatopathol
Eyelid sebaceous carcinoma: clinicopathologic and multiparametric immunohistochemical analysis that includes adipophilin
Am J Ophthalmol
Nuclear factor XIIIa staining (clone AC-1A1 mouse monoclonal) is a sensitive and specific marker to discriminate sebaceous proliferations from other cutaneous clear cell neoplasms
J Cutan Pathol
Nuclear factor XIIIa staining (clone AC-1A1 mouse monoclonal) is a highly sensitive marker of sebaceous differentiation in normal and neoplastic sebocytes
J Cutan Pathol
Lipid synthesis and processing proteins ABHD5, PGRMC1 and squalene synthase can serve as novel immunohistochemical markers for sebaceous neoplasms and differentiate sebaceous carcinoma from sebaceoma and basal cell carcinoma with clear cell features
J Cutan Pathol
“Ripple pattern” in a neoplasm signifies sebaceous differentiation [sebaceoma (not trichoblastoma or trichomatricoma) if benign and sebaceous carcinoma if malignant]
Dermatopathol: Prac & Conc
Sebaceous neoplasm with reticulated and cribriform features: a rare variant of sebaceoma
J Cutan Pathol
Rippled-pattern sebaceoma: a clinicopathological study
Am J Dermatopathol
Rippled-pattern sebaceoma: a report of a lesion on the back with a review of the literature
Am J Dermatopathol
Sebaceoma and related neoplasms with sebaceous differentiation: a clinicopathologic study of 30 cases
Am J Dermatopathol
Trichoblastoma with rippled-pattern
J Dermatol
Cited by (32)
Widespread sebaceous neoplasms in the setting of chronic immunosuppression with near-complete clearance on isotretinoin
2022, JAAD Case ReportsCitation Excerpt :Sebaceous neoplasms encompass a broad set of diagnoses ranging from benign entities, such as sebaceous adenomas and sebaceoma, to more concerning malignancies, such as sebaceous carcinoma.1
Sebaceous “adenoma” of an arm recurring as a carcinoma: The value of DNA mismatch repair gene expression immunohistochemistry
2022, JAAD Case ReportsCitation Excerpt :Immunohistochemistry to detect mutated mismatch repair genes is commonly performed on sebaceous neoplasms to screen for Muir-Torre syndrome.1
Eruptions of Sebaceous Adenomas and Carcinomas Induced by Tacrolimus
2021, Actas Dermo-SifiliograficasCutaneous Tumors and Pseudotumors of the Head and Neck
2020, Gnepp's Diagnostic Surgical Pathology of the Head and Neck, Third EditionSebaceous adenoma in the setting of immunosuppression for kidney transplantation
2019, JAAD Case ReportsCitation Excerpt :Growth pattern is often insidious and asymptomatic, rarely presenting with symptoms of irritation. The head and neck region is the most common location, but lesions may arise in any area.5 Because sebaceous adenomas are benign, treatment for most individuals is conservative management, although bothersome lesions can be removed for patient comfort.
Sebaceoma on the scalp simulating a malignant pigmented neoplasia
2019, Anais Brasileiros de Dermatologia