CorrespondenceScalp Cooling therapy and cytotoxic treatment
References (1)
- et al.
Prevention of chemotherapy-induced alopecia using an effective scalp cooling system
Eur J Cancer
(2000)
Cited by (25)
Hair disorders in patients with cancer
2019, Journal of the American Academy of DermatologyCitation Excerpt :In a multicenter, randomized study using the Paxman Orbis scalp cooling system,152 hair preservation was observed in 50% (cooling group) versus 0% (controls) after the fourth chemotherapy cycle (taxane/anthracycline or both). Another prospective randomized study of 79 patients (41 receiving Dignicap scalp cooling) reported lower hair preservation rates (39%) among patients undergoing scalp cooling versus 0% in the no scalp cooling arm.157,158 Differences between devices are likely related to operator experience and types of chemotherapy regimens of patients enrolled, with patients undergoing taxane-based regimens showing a higher benefit from scalp cooling.
Supportive cryotherapy: A review from head to toe
2014, Journal of Pain and Symptom ManagementCitation Excerpt :Rare side effects include nausea, dizziness, or anxiety.76,77 Two case reports of scalp metastases associated with scalp hypothermia in patients with hematological malignancies have been reported.78,79 Although similar concerns have been raised in patients with solid tumors, more recent evidence suggests that this risk is minimal.
Chemotherapy-induced alopecia
2012, Journal of the American Academy of DermatologyCitation Excerpt :One patient with mycosis fungoides, a cutaneous lymphoma, developed recurrent disease limited to the scalp after chemotherapy with cooling cap use.49 Another patient with acute myeloblastic leukemia developed tumors in the scalp after initial complete hematologic remission after chemotherapy with cooling cap use.50 It is advised that scalp cooling systems not be used in patients with circulating malignant cells such as leukemia or lymphoma who are receiving chemotherapy with curative intent.48
Effectiveness of scalp cooling in chemotherapy
2011, Bulletin du CancerThe role of iron and zinc in chemotherapy-induced alopecia
2005, Journal of Quantitative Spectroscopy and Radiative TransferCitation Excerpt :Several methods including scalp cooling, some topically applied agents have been used for the prevention of alopecia [7–9]. However, some of these methods such as cooling, which decreases the blood perfusion of the scalp, may be a risk for relapse in patients with leukemia [10]. Therefore, new studies are needed to disclose the pathogenesis and for safely prevention of chemotherapy-induced alopecia.
Scalp cooling to prevent chemotherapy-induced alopecia
2020, Anais Brasileiros de DermatologiaCitation Excerpt :Witman et al. reported a case of mycosis fungoides that disappeared with consolidation chemotherapy but recurred on the scalp.64 Another instance of relapse was described in a 17-year-old boy whose acute myeloblastic leukemia manifested with several subcutaneous scalp nodules but with no evidence of hematological relapse seven years after the use of scalp cooling during his two courses of chemotherapy.65 Scalp cooling has been shown to be a well-tolerated supportive care.49,66