The treatment of severe cystic acne with 13-cis-retinoic acid: Evaluation of sebum production and the clinical response in a multiple-dose trial*
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Photodynamic therapy in cosmetics
2023, Nanomaterials for Photodynamic TherapyAn insight into photodynamic therapy towards treating major dermatological conditions
2022, Journal of Drug Delivery Science and TechnologyCitation Excerpt :Acne, also known as acne vulgaris manifests as inflammation in the epidermis due to increased production of sebum which is cosmetically disabling as the affected individual becomes conscious and is prone to undergo depression or anxiety and also lose confidence due to the same [67–70]; bacterial species Propionibacterium acnes is also involved in its pathology [71–73]. Conventional treatments of acne include applying formulations containing salicylic acid, retinoic acid, benzoyl peroxide, azelaic acid, and antibiotics which facilitate the clearing of pores and keeping a check on microbial load respectively [74,75]. Glycolic acid is another alternative that works by breaking down oily plugs that get accumulated in pores.
Consensus on the use of oral isotretinoin in dermatology - Brazilian Society of Dermatology
2020, Anais Brasileiros de DermatologiaCitation Excerpt :Some controversies about rare and serious events, particularly depression, suicide, and inflammatory bowel disease (IBD), have not been proven to be causally associated.40 It was approved for severe acne (conglobata and nodular-cystic), but evidence demonstrated in controlled randomized clinical trials (CRCTs) since 1980, in systematic reviews (SRs), consensuses, and recommendations of dermatology societies allowed to expand the indication for nodular-cystic and moderate papulopustular forms resistant to other treatments, with tendency to scarring, and emotional and social functional impairment.1,2,36,38,40–74 A single course of the drug leads to cure in two-thirds of patients.
Current understanding of potential ecological risks of retinoic acids and their metabolites in aquatic environments
2020, Environment InternationalCitation Excerpt :Besides, retinoids are commonly used in drugs and food industries since various isomers of RAs exhibit various functions (Lucek and Colburn, 1985). For instance, 30 mg 9c-RA/day effectively treated Pityriasis rubra pilaris (Amann et al., 2015); and a maximum of 1.2 mg 13c-RA/kg/day is used to cure cystic acne (Farrell et al., 1980; Peck et al., 1982). More importantly, at-RA is effective at treating acute promyelocytic leukaemia (Huang et al., 1988; Wang and Chen, 2008).
The effect of low-dose isotretinoin therapy on serum androgen levels in women with acne vulgaris
2020, International Journal of Women's DermatologyCitation Excerpt :Isotretinoin has a profound inhibitory effect on the size and function of sebaceous glands, resulting in reduction of acne lesions. Evidence suggests that isotretinoin’s therapeutic function is independent of hormonal mediation (Farrell et al., 1980); however, the effect of isotretinoin on serum androgens and precursor androgen levels in humans remains unclear (Feily and Namazi, 2011; Gomez and Moskowitz, 1980; Lookingbill et al., 1988; Marynick et al., 1983). Herein, we investigate the effect of low-dose isotretinoin on androgen levels in women and postulate the role of concomitant anti-androgen therapy.
Photodynamic Therapy for Photodamage, Actinic Keratosis, and Acne in the Cosmetic Practice
2020, Facial Plastic Surgery Clinics of North AmericaCitation Excerpt :Typical acne treatments have been combined topical treatments. Retinoic acid with a topical antibiotic have conventionally been used.85 The retinoic acid is used to eliminate the cell accumulation that blocks the pores and the topical antibiotic keeps the bacteria count in the pore down to decrease the oil breakdown that leads to inflammation.86
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Supported in part by a grant from Hoffmann-La Roche Inc., and by a research grant (RO-1-AM-22083-02) from the United States Public Health Service.