Psychotropic drugs in dermatology: A review and guidelines for use

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A review of the literature on the use of psychotropic drugs in dermatologic practice—including the antipsychotic, antidepressant, antianxiety, and hypnotic medications, as well as their pharmacologic properties, guidelines for clinical use, and a profile of adverse effects—is presented. After adverse effects and current guidelines for use are taken into consideration, it is suggested that psychotropic drugs be restricted to dermatologic conditions with clearly discernible psychiatric symptoms, for example, psoriasis and major depression, vitiligo resulting in social anxiety, and delusions of parasitosis. The pharmacologic properties of psychotropic drugs, such as the analgesic properties of certain antidepressants, may be of benefit in the treatment of dermatologic symptoms such as intractable pruritus, since pain and pruritus share the same central nervous system pathways. This use of psychotropic drugs remains to be evaluated by well-designed clinical trials.

References (67)

  • CS Koblenzer

    Psychosomatic concepts in dermatology, a dermatologist-psychoanalyst's viewpoint

    Arch Dermatol

    (1983)
  • EP Lester et al.

    Phrenotropic drugs in psychosomatic disorders (skin)

    Am J Psychiatry

    (1962)
  • SW Levy

    A psychosomatic approach to the management of recalcitrant dermatoses

    Psychosomatics

    (1963)
  • O Hagermark

    Influence of antihistamines, sedatives and aspirin on experimental itch

    Acta Derm Venereol (Stockh)

    (1973)
  • S Friedman et al.

    On the treatment of neurodermatitis with a monoamineoxidase inhibitor: The chemotherapy of psychosomatic illness through A-REM suppression

    J Nerv Ment Dis

    (1978)
  • K Hamann et al.

    Delusions of infestations treated by pimozide: A double-blind crossover clinical study

    Acta Derm Venereol (Stockh)

    (1982)
  • SA Muller

    Psychocutaneous disorders and neurogenic skin diseases

  • S Bloomfield et al.

    Comparative analgesic activity of levomepromazine and morphine in patients with chronic pain

    Can Med Assoc J

    (1964)
  • JR Herndon

    Itching: The pathophysiology of pruritus

    Int J Dermatol

    (1975)
  • K Hamann

    Onychotillomania treated with pimozide (Crap)

    Acta Derm Venereol (Stockh)

    (1982)
  • AJ Gellenberg

    Psychoses

  • RM Pinder et al.

    Pimozide: A review of its pharmacological properties and therapeutic uses in psychiatry

    Drugs

    (1976)
  • SC Schoonover

    Depression

  • WD Stewart et al.
  • B Blackwell

    Antidepressant drugs

  • A Satanove

    Pigmentation due to phenothiazines in high and prolonged dosage

    Jama

    (1965)
  • MH Zarrabi et al.

    Immunologic and coagulation disorders in chlorpromazine-treated patients

    Ann Intern Med

    (1979)
  • S McNevin et al.

    Chlorprothixene-induced systemic lupus erythematosus

    J Clin Psychopharmacol

    (1982)
  • GM Simpson et al.

    Neuroleptics and antipsychotics

  • LY Matsuoka

    Thiothixene drug sensitivity

    J Am Acad Dermatol

    (1982)
  • GL Bakris et al.

    Dermatologic manifestations of lithium: A Review

    Int J Psychiatry Med

    (1981)
  • D Deandrea et al.

    Dermatological reactions to lithium: A critical review

    J Clin Psychopharmacol

    (1982)
  • Cited by (0)

    **

    Currently also with the Department of Psychiatry, University of Michigan, Ann Arbor, MI.

    ****

    Now with the Department of Dermatology, University of Michigan, Ann Arbor, MI.

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