Treatment and prevention of basal cell carcinoma with oral isotretinoin
References (26)
The effect of vitamin A acid on hyperkeratin-ization and the keratoacanthoma
J Invest Dermatol
(1967)- et al.
Topical vitamin A acid therapy for cutaneous metastatic melanoma
Lancet
(1980) Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cells
Biochim Biophys Acta
(1980)- et al.
Chemoprevention of basal cell carcinoma with isotretinoin
J Am Acad Dermatol
(1982) - et al.
Vertebral abnormalities associated with synthetic retinoid use
J Am Acad Dermatol
(1984) Retinoids and the immune system: immunostimulation of vitamin A
- et al.
Retinoids and cancer
- et al.
Retinoids, a new class of compounds with prophylactic and therapeutic activities in oncology and dermatology
Experientia
(1978) - et al.
Treatment of keratoacanthomas with oral 13-cis-retinoic acid
New Engl J Med
(1980) - et al.
Phase II trial of 13-cis-retinoic acid in metastatic breast cancer and other malignancies
Proc Am Soc Clin Oncol
(1981)
Retinoids in clinical dermatology
Topical aromatic retinoid in the treatment of ichthyosis vulgaris
Metastatic basal cell carcinoma
J Dermatol Surg Oncol
Cited by (101)
Consensus on the use of oral isotretinoin in dermatology - Brazilian Society of Dermatology
2020, Anais Brasileiros de DermatologiaCitation Excerpt :Details of the studies that used it for treatment are presented in Table 5.172–175 The reported indications for prevention include: multiple non-melanoma skin cancers (> 5 per year); multiple actinic keratoses (AKs); eruptive keratoacanthomas or occurring in transplanted and/or immunosuppressed patients, xeroderma pigmentosum, exposure to chronic phototherapy, and verruciform epidermodysplasia.171,176–183 Little is known about the use of retinoids in multiple AKs and field cancerization in immunocompetent or immunodepressed patients, at risk of developing non-melanoma skin cancer.
Familial skin cancer syndromes Increased risk of nonmelanotic skin cancers and extracutaneous tumors
2016, Journal of the American Academy of DermatologyCitation Excerpt :As in cases of sporadic BCC, excision as well as electrodessication and curettage are often used; however, because of concerns of disfigurement and discomfort from multiple surgical procedures, CO2 laser therapy in combination with Mohs micrographic surgery can be an option in select patients.23 In addition, superficial BCCs can be managed by topical 5% 5-fluorouracil (5-FU), topical imiquimod, or photodynamic therapy.24-27 A placebo controlled phase III randomized trial has also found that vismodegib, a smoothened (SMO) antagonist and SHH pathway inhibitor, can reduce the tumor burden in patients with BCNS.28
Retinoic acid and the ocular surface
2015, Survey of OphthalmologyCitation Excerpt :These applications indicate that retinoic acid has the potential to contain, but not cure, neoplastic lesions.153 Since then, many authors have demonstrated the ability of retinoic acid, in synergistic combination with other agents such as interferon, to treat and sometimes even reverse squamous metaplasia in the eye50,152,171,172,185 and other areas of the body, including the skin, cervix, and breast cancer cell lines.3,59,78,113,123 Currently, interferon alpha-2b has been combined with retinoic acid 0.01% twice daily to treat ocular surface dysplasias.143
Basal cell nevus syndrome: From DNA to therapeutics
2020, Clinics in DermatologyCitation Excerpt :Although no controlled trials have definitively established the validity of this measure in this population, its efficacy can be inferred by the reduced prevalence of BCCs in African Americans with this syndrome.4 Several studies suggest that chemoprevention with systemic retinoids (isotretinoin >4 mg/kg and etretinate 0.7 to 1 mg/kg) may reduce the rate of development of new BCCS47,48; however, the clinical benefits are less than those seen in patients with multiple cutaneous SCCs and must be balanced against the potential adverse effects associated with chronic systemic retinoid exposure. Secondary prevention involves close surveillance of BCNS patients in an effort to promote earlier detection and treatment of new lesions.
The Use of Retinoids for the Prevention and Treatment of Skin Cancers: An Updated Review
2022, International Journal of Molecular Sciences
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From the Dermatology Branch, National Cancer Institute