TY - JOUR T1 - Analysis of filaggrin 2 gene polymorphisms in patients with atopic dermatitis JO - Anais Brasileiros de Dermatologia (Portuguese) T2 - AU - Hertz,Amanda AU - Azulay-Abulafia,Luna AU - Nascimento,Adriana Paulino do AU - Ohara,Cintya Yumi AU - Kuschnir,Fabio Chigres AU - Porto,Luís Cristovão SN - 03650596 M3 - 10.1016/j.abd.2019.07.002 DO - 10.1016/j.abd.2019.07.002 UR - http://www.anaisdedermatologia.org.br/pt-analysis-filaggrin-2-gene-polymorphisms-articulo-S0365059620300192 AB - BackgroundPolymorphisms of the filaggrin 2 gene (rs 12568784 and rs 16899374) are associated with persistent atopic dermatitis in African American patients. Filaggrin 2 is a protein with a function similar to filaggrin and also encoded in the epidermal differentiation complex on chromosome 1q21. ObjectiveTo evaluate the polymorphisms in the filaggrin 2 gene (rs 12568784 and rs 16899374) in children and adults with atopic dermatitis and to verify the association of these with the severity of the clinical picture, presence of other allergic diseases, and socio-demographic factors. MethodThe study was carried out with patients and control group. Questionnaires were used to evaluate ethnicity, sex, age, family history, scoring, atopic dermatitis (SCORAD), among other parameters. Genotyping of the filaggrin 2 gene was performed by real-time polymerase chain reaction. ResultsForty-eight patients and 83 controls were evaluated. No correlation was found between the variables studied in patients with atopic dermatitis and polymorphisms, no significant difference between the prevalence of polymorphisms in the patients and in the control group p>0.05. Study limitsThe exclusive use of self-reported ethnicity information and the sample size. ResultsThe results of this work can be an incentive for the study of the polymorphisms in atopic dermaititis, considering the characteristic of the Brazilian multi ethnic population. ConclusionThis is an unpublished work in Brazil and the first study in the world to have a control group to evaluate alterations in the gene of filaggrin 2. ER -