TY - JOUR T1 - Clinical aspects and therapeutic approach of drug-induced adverse skin reactions in a quaternary hospital: a retrospective study with 219 cases JO - Anais Brasileiros de Dermatologia (Portuguese) T2 - AU - Martins,JĂșlia Chain AU - Seque,Camila Arai AU - Porro,Adriana Maria SN - 03650596 M3 - 10.1016/j.abd.2021.06.008 DO - 10.1016/j.abd.2021.06.008 UR - http://www.anaisdedermatologia.org.br/pt-clinical-aspects-therapeutic-approach-drug-induced-articulo-S0365059622000253 AB - BackgroundAdverse drug reactions are frequent, with cutaneous manifestations being the most common. In the hospital environment, the incidence of cutaneous drug reactions varies from 2% to 3%. ObjectiveTo analyze the profile of cutaneous drug reactions, relating clinical forms, suspected medications, histopathological alterations, systemic repercussions, treatment and course. MethodsClinical, retrospective and observational study of patients seen by the Dermatology Interconsultation team from January 2013 to December 2016. ResultsThe frequency of cutaneous drug reactions among the evaluated patients was 13.6%, with 219 cases diagnosed. In 65.7%, the reaction was considered mild, of which the most common was exanthema, while in 34.2%, the reaction was considered severe, with DRESS being the main form of reaction(18.2%). Antibiotics (36.5%) and anticonvulsants (10%) were the most involved drugs. In addition to drug discontinuation, systemic corticosteroids were prescribed in 47% of cases and intravenous immunoglobulin (IVIg) in 4.5%. Of the mild forms, in 62%, expectant management and/or exclusive use of symptomatic treatment was used. Study limitationsRetrospective study, with limitations inherent to this type of investigation; lack of some information in medical records; long evaluation period, with a possible change in external validity. ConclusionThe most frequently identified clinical form was exanthema, and antibiotics and anticonvulsants were the most frequently involved drug classes. About one-third of the patients had severe cutaneous drug reactions, with DRESS being the main one. Cutaneous drug reactions are frequent in clinical practice, and the dermatologist should be called in as soon as possible to assist in the diagnosis and management of these cases. ER -