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Vol. 93. Issue 3.
Pages 391-396 (01 May 2018)
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Vol. 93. Issue 3.
Pages 391-396 (01 May 2018)
Open Access
Development and validation of a multidimensional questionnaire for evaluating quality of life in melasma (HRQ-melasma)*
Camila Fernandes Pollo1, Silmara Meneguin1, Luciane Donida Bartoli Miot2, Hélio Amante Miot2
1 Department of Nursing, Faculdade de Medicina de Botucatu - Universidade Estadual Paulista (FMB-Unesp), Botucatu (SP), Brazil.
2 Department of Dermatology, Faculdade de Medicina de Botucatu - Universidade Estadual Paulista (FMB-Unesp), Botucatu (SP), Brazil.
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Tables (5)
Table 1. Clinical, demographic, and quality of life data in patients with facial melasma
Chart 1:. Version of HRQ-Melasma in Brazilian Portuguese
Table 2. Spearman’s correlation (rho) for total score and dimensions of HRQ-Melasma
Table 3. Spearman’s correlations (rho), item-item and item-total HRQ-Melasma
Table 4. Spearman’s correlation (rho) for clinical, self-image, and quality of life instruments applied in the study
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Background: Melasma has a major impact on quality of life. MELASQoL is the only validated specific psychometric instrument to evaluate melasma QoL.

Objective: To develop and validate a multidimensional questionnaire for evaluating quality of life related to facial melasma.

Methods: Cross-sectional study performed in 2 institutions (public and private) from Brazil. Two focus groups were carried out: 5 board-certified dermatologists and 10 melasma patients, indicating the dimensions and significant units of melasma QoL. The preliminary questionnaire with 49 itens was applied to 154 facial melasma patients. Item reduction was performed by Rasch analysis. Parallel evaluations of clinical (MASI), demographic, and QoL aspects (MELASQoL, DLQI) were performed. The dimensional structure was assessed by confirmatory factor analysis. Temporal stability was tested in a subgroup of 42 individuals within 7-14 days.

Results: The mean (SD) age of the 154 interviewed subjects was 39±8 years, and 87% were females. The median (p25-p75) DLQI and MELASQoL were: 2 (1-6) and 30 (17-44). HRQ-Melasma consisted of 19 items distributed in 4 dimensions: Physical/Appearance, Social/Professional, Psychological, and Treatment. Cronbach’s alpha for HRQ-Melasma was 0.96, and >0.74 for each dimension. There was high correlation between HRQ-Melasma and DLQI and MELASQoL (rho=0.80 and 0.83), but modest with MASI (rho=0.35). Dimensional structure of HRQ-Melasma was stated by confirmatory factor analysis coefficients. Test-retest analysis disclosed an intraclass correlation coefficient of 0.91 (p<0.01).

Study limitations: Single-center study.

Conclusions: A specific instrument to evaluate QoL in melasma with multidimensional characteristics was developed and validated, with appropriate psychometric performance.

Quality of life
Full Text

Melasma is a common chronic hypermelanosis characterized by symmetrical hyperchromic macules on photo-exposed skin, mainly the face. It occurs most frequently in childbearing-age women. Despite treatment, lesions tend to recur.1,2

Dermatoses can influence self-image and have the potential to trigger processes which affect self-esteem, promoting feelings of anxiety, unhappiness, or even depressive disorders. Although asymptomatic, melasma affects visible areas and has an important impact on quality of life (QoL).3-6

The World Health Organization defines QoL as “individuals’ perception of their position in life in the context of the culture and value systems in which they live and in relation to their goals, expectations, standards, and concerns”.7 Meanwhile, health-related quality of life, which is a broad general concept that can vary significantly among different populations and cultures, is being used as an outcome in clinical trials.8

In 2003, the only specific instrument for evaluating melasma-related QoL was developed and validated: MELASQoL (Melasma Quality of Life Scale). The authors based it on SKINDEX-16 (7 items) and a questionnaire on changes in skin color (3 items).9 MELASQoL has been adapted and validated in different countries and used in various clinical trials.10-18

Criticisms have been raised about the construction process and application of MELASQoL, including: difficulties in the semantic interpretation of items, having been validated only in women, no prior qualitative analysis of perception about the disease, low representation of the dimension of feelings and self-esteem, lack of psychometric studies in relation to scalability, and temporal stability.19 These arguments indicate a need for developing new tools for evaluating QoL in melasma.

In this study we developed and validated a multidimensional instrument for evaluating QoL related to facial melasma in Brazil.


This was a cross-sectional study performed at the School of Medicine of Unesp (Botucatu-SP), Brazil, from April 2014 to July 2015. The research project was approved by the Institutional Review Board of the institution (case review no. 476.666 / CAAE 24564413.3.0000.5411).

Patients were recruited from 2 institutions: FMB-Unesp Dermatology Outpatient Clinic (public) and Clínica Laura Buratini (private), in Botucatu, SP, Brazil.

Participation in the study included: 1) board-certified dermatologists and 2) patients with facial melasma over 18 years of age and from both genders, without other facial dyschromia.

Focus Groups

The first focus group consisted of 5board-certified dermatologists responding to the guided question: “In which aspects does melasma upset the life of patients?” This group oriented the main dimensions affected by melasma.

The second focus group consisted of 10 melasma patients recruited from the 2 institutions, responding to the guided question: “In your opinion, how does melasma affect your life?” within each dimension identified by the first focus group. These patients were selected on the basis of suitable intellectual and educational level for the discussion. This group provided information for item elaboration.

Both focus groups followed methodological steps: building a script of issues, formulation of representativeness criteria, and data collection on different individual perceptions.

The answers were recorded and analyzed according to Bardin content analysis, based on a preliminary definition of the dimensions affected by melasma (first focus groups).20

Content Analysis

The narratives were analyzed by following the steps of content analysis, in 3 phases. Pre-analysis: the organizational stage of the material and systematization of ideas; exploration of material: consisted of the data categorization operation in the transformation of raw data in order to achieve a core understanding of the text. This stage included cropping (selection of units of meaning) and data categorization. The last step was processing and interpretation of results.

The dermatologists’ narratives were transcribed, and the instrument’s dimensions emerged from these.

Patient narratives were transcribed and summarized to identify significant units, resulting in the preliminary composition of items for each dimension of the instrument.

Semantic Adaptation and Content Validation

The preliminary questionnaire, defined with 49 items in 7 dimensions, was analyzed by 5 specialists for item suitability (face validation) and semantics, and was also submitted to 10 patients for semantic and cultural adjustments to the items.

Data Collection

The preliminary questionnaire was applied to 154 facial melasma patients. Parallel evaluations were performed of clinical aspects (MASI – Melasma Area Severity Index), visual analogue scale for self-perception of inconvenience with 5 levels (developed for this study), and demographic and quality of life aspects: MELASQoL-PB, DLQI-BRA.9,11,21-23

A convenience sample was used, with patients included after giving informed consent to participate in the study.

Item Reduction

The performance of items within each dimension was analyzed according to Item Response theory: polytomous Rasch model for ordinal data (Samejima graded model).24-26

Questionnaire reduction was accomplished according to the contribution of information from each item within each dimension, with low-informativity items being excluded.27,28

Questionnaire Validation

Validation of the reduced questionnaire (HRQ-Melasma) was performed by evaluating the internal consistency and correlation with other quality of life instruments (concurrent validity).

Dimensional Evaluation

The dimensional structure of HRQ-Melasma was tested by confirmatory factor analysis. Adjustment of the multidimensional model was performed through the following tests: chi-square by degrees of freedom ratio (CMIN/DF), adjusted goodness-of-fit index (AGFI), comparative fit index (CFI), and root mean square error of approximation (RMSEA).29,30

Temporal Stability

Test-retest stability of the final construct (HRQ-Melasma) and MELASQoL-BP in a subgroup of 42 individuals was analyzed 7-14 days after the interviews.

Statistical Analysis

Categorical variables were represented by their absolute values and percentage frequencies. Quantitative data were represented by means and standard deviations or medians and quartiles (p25-p75) if normality was not observed with the Kolmogorov-Smirnov test (Lilliefors).31

Correlation between HRQ-Melasma, MELASQoL-PB, DLQI-BRA, MASI, and visual scale of inconvenience scores were evaluated by Spearman’s rank correlation coefficient (rho).31

Analysis of the internal consistency of the scale and dimensions was performed by Cronbach’s alpha coefficient.32

Test-retest stability was evaluated by the intraclass correlation coefficient (ICC) for complete agreement.33

Scaling of HRQ-Melasma scores was based on the projection of DLQI categories22 using the cubic regression technique.

Data were tabulated in MS Excel 2010 spreadsheets and analyzed by IBM SPSS 22, eirt-1.3, and AMOS 10 software packages.34,35 Significance was set at p<0.05.

Sample size was based on a pre-test interview of 100 individuals, performing an estimate of more than 10 cases per item within each dimension.36


Of the 154 individuals interviewed, 87 (57%) were recruited from the outpatient clinic of a public university hospital and 67 (43%) from a private clinic. The main clinical and demographic data are shown in table 1. There was a predominance of females, and disease onset during childbearing age.

Table 1.

Clinical, demographic, and quality of life data in patients with facial melasma

Variables    N (%) 
Age (years)*    39 (8) 
Sex  Female  134 (87) 
  Male  20 (13) 
Marital status  Single  42 (27) 
  Married/Stable union  93 (60) 
  Widow(ed)  19 (12) 
Schooling  Elementary  28 (18) 
  Secondary  50 (33) 
  University  76 (49) 
Monthly family income  < BRL 1,000.00  20 (13) 
  BRL 1,100-3,000.00  51 (33) 
  BRL 3,000-5,000.00  36 (23) 
  > BRL 5,000.00  47 (31) 
Age at onset of melasma (years)*    27 (8) 
Duration (years)**    10 (6-16) 
MASI**    8 (5-15) 
Visual scale  1 – Not bothered  14 (9) 
  2 – Slightly bothered  25 (16) 
  3 – Moderately bothered  43 (28) 
  4 - Very bothered  34 (22) 
  5 – Extremely bothered  38 (25) 
DLQI-BRA**    2 (1-6) 
MELASQoL-PB**    30 (17-44) 
HRQ- MELASMA **    31 (15-52) 

Mean (standard deviation); **Median (p25-p75)

The first focus group (dermatologists) initially indicated 7dimensions. The second focus group (patients) led to the elaboration of 65 items which were later grouped into 49 items within 4 dimensions.

The test questionnaire was revised after a semantic review by patients and specialists, as well as validation of content, clarity, objectivity, appropriateness of terms, and ease of understanding, by specialists (data not shown). The test questionnaire with 49 items was then applied to 154 melasma patients.

The item reduction process within each dimension was based on the function of information expressed by each item according to Rasch analysis. The reduced questionnaire (HRQ-Melasma) resulted in 19 items (Chart 1) distributed in 4 dimensions (Physical/Appearance, Social/Professional, Psychological, and Treatment).

Chart 1:.

Version of HRQ-Melasma in Brazilian Portuguese

The aim of this questionnaire is to measure how much the patches on your skin affected your life IN THE LAST 30 DAYS. Please mark the best answer to each question with an “X”.
In the last 30 days how did you feel because of your patches?
PA1-How often did you feel that the patches made you look less beautiful (or handsome)?
( )0.Never/Does not apply  ( )1.Rarely  ( )2.Sometimes  ( )3.Often  ( )4.Always 
PA2-How often, because of the patches, did you feel you look older than you really are?
( )0.Never/ Does not apply  ( )1.Rarely  ( )2.Sometimes  ( )3.Often  ( )4.always 
PA3-How often, because of the patches, did you feel different from other people?
( )0.Never/Does not apply  ( )1.Rarely  ( )2.Sometimes  ( )3.Often  ( )4. Always 
SP4-How often did the presence of the patches interfere in your activities or work?
( )0.Never/ Does not apply  ( )1.Rarely  ( )2.Sometimes  ( )3.Often  ( )4.Always 
SP5- Because of your patches, how often did you feel uncomfortable meeting new people?
( )0.Never/ Does not apply  ( )1.Rarely  ( )2.Sometimes  ( )3.Often  ( )4.Always 
SP6-How often did you feel bothered participating in daytime commitments?
( )0.Never/ Does not apply  ( )1.Rarely  ( )2.Sometimes  ( )3.Often  ( )4.Always 
SP7-How often did the patches interfere in your seeking new job opportunities?
( )0.Never/ Does not apply  ( )1.Rarely  ( )2.Sometimes  ( )3.Often  ( )4.Always 
SP8-How often did the patches limit your social activities, such as commitments, meetings, or interpersonal relations?
( )0.Never/ Does not apply  ( )1.Rarely  ( )2.Sometimes  ( )3.Often  ( )4. Always 
PSY9-How often did you feel discouraged because your patches were a chronic, incurable problem?
( )0.Never/ Does not apply  ( )1.Rarely  ( )2. Sometimes  ( )3.Often  ( )4.Always 
PSY10-How often did you feel bothered by comments or questions by other people about your patches?
( )0.Never/ Does not apply  ( )1.Rarely  ( )2.Sometimes  ( )3.Often  ( )4.Always 
FA11-How often did you think your patch looked ugly?
( )0.Never/ Does not apply  ( )1.Rarely  ( )2.Sometimes  ( )3.Often  ( )4.Always 
PSY12-How often did you feel ashamed of your patches?
( )0.Never/ Does not apply  ( )1.Rarely  ( )2.Sometimes  ( )3.Often  ( )4.Always 
PSY13-How often did you avoid or feel bad looking in the mirror because of the patches?
( )0.Never/ Does not apply  ( )1.Rarely  ( )2.Sometimes  ( )3.Often  ( )4.Always 
PSY14-How often did you feel bothered when other people stared at you and noticed the patches?
( )0.Never/ Does not apply  ( )1.Rarely  ( )2.Sometimes  ( )3.Often  ( )4.Always 
PSY15-How often did you feel sad or depressed because of the patches?
( )0.Never/ Does not apply  ( )1.Rarely  ( )2.Sometimes  ( )3.Often  ( )4.Always 
PSY16-How often did you have trouble accepting the patches?
( )0.Never/ Does not apply  ( )1.Rarely  ( )2.Sometimes  ( )3.Often  ( )4.Always 
RX17-How often did you find that the treatment products or sunscreens were not adapted to your kind of skin?
( )0.Never/ Does not apply  ( )1.Rarely  ( )2.Sometimes  ( )3.Often  ( )4.Always 
RX18-In the last 30 days, how often did you feel bothered by the side effects from the treatment? For example: redness.
RX19-How often did you feel bothered because the patches got darker in spite of the treatment?
( )0.Never/ Does not apply  ( )1.Rarely  ( )2.Sometimes  ( )3.Often  ( )4.Always 

High correlation was seen between test questionnaire scores and HRQ-Melasma (rho = 0.98; p<0.01).

Internal consistency (Cronbach’s alpha) for HRQ-Melasma was 0.96, and as follows for the 4 dimensions: Physical/Appearance (0.88), Social/Professional (0.92), Psychological (0.94), and Treatment (0.74). There was high correlation between total and dimension scores (Table 2). Item-item correlations are shown in table 3.

Table 2.

Spearman’s correlation (rho) for total score and dimensions of HRQ-Melasma

  Total SP  Total PSY  Total RX  HRQ-Melasma 
Total PA  0.68  0.85  0.55  0.91 
Total SP    0.73  0.45  0.81 
Total PSY      0.63  0.96 
Total RX        0.71 

PA- Physical/Appearance SP- Social/Professional PSY- Psychological RX- Treatment

Table 3.

Spearman’s correlations (rho), item-item and item-total HRQ-Melasma

  PA2  PA3  PA18  SP6  SP7  SP10  SP11  SP12  PSY15  PSY16  PSY21  PSY23  PSY25  PSY28  PSY30  RX39  RX45  RX46  HRQ-Melasma 
PA1  0.69  0.66  0.71  0.42  0.51  0.47  0.46  0.42  0.70  0.61  0.73  0.65  0.63  0.53  0.60  0.33  0.35  0.52  0.80 
PA2    0.69  0.64  0.48  0.55  0.48  0.50  0.50  0.59  0.61  0.66  0.59  0.64  0.61  0.59  0.30  0.39  0.49  0.78 
PA3      0.56  0.59  0.59  0.52  0.51  0.53  0.60  0.62  0.66  0.63  0.67  0.62  0.58  0.25  0.29  0.46  0.78 
PA18        0.45  0.49  0.46  0.39  0.41  0.72  0.58  0.70  0.61  0.63  0.53  0.59  0.33  0.36  0.58  0.78 
SP6          0.65  0.70  0.65  0.73  0.50  0.54  0.57  0.55  0.54  0.61  0.49  0.23  0.25  0.40  0.69 
SP7            0.64  0.61  0.64  0.48  0.56  0.63  0.63  0.56  0.57  0.44  0.29  0.24  0.42  0.71 
SP10              0.64  0.72  0.51  0.53  0.59  0.63  0.53  0.59  0.56  0.27  0.25  0.45  0.72 
SP11                0.66  0.47  0.53  0.52  0.53  0.49  0.63  0.46  0.21  0.25  0.33  0.65 
SP12                  0.50  0.49  0.55  0.55  0.55  0.58  0.46  0.26  0.28  0.45  0.69 
PSY15                    0.68  0.77  0.66  0.70  0.62  0.64  0.32  0.42  0.71  0.84 
PSY16                      0.73  0.66  0.80  0.61  0.61  0.36  0.52  0.59  0.83 
PSY21                        0.75  0.80  0.71  0.70  0.26  0.41  0.60  0.88 
PSY23                          0.71  0.66  0.63  0.33  0.37  0.50  0.83 
PSY25                            0.66  0.65  0.31  0.44  0.59  0.84 
PSY28                              0.63  0.24  0.34  0.47  0.78 
PSY30                                0.37  0.40  0.50  0.76 
RX39                                  0.45  0.41  0.45 
RX45                                    0.57  0.53 
RX46                                      0.72 

PA- Physical/Appearance SP- Social/Professional PSY- Psychological RX- Treatment

Correlations between HRQ-Melasma and clinimetric or quality of life scores are shown in table 4. There was only modest correlation between MELASQoL-PB and HRQ-Melasma and MASI. However, there was strong correlation between HRQ-Melasma and DLQI-BRA and MELASQoL-PB.

Table 4.

Spearman’s correlation (rho) for clinical, self-image, and quality of life instruments applied in the study

  MELASQOL-BP  DLQI-BRA  Visual Scale  HRQ-Melasma 
MASI  0.35  0.27  0.39  0.35 
MELASQoL-BP    0.73  0.72  0.83 
DLQI-BRA      0.67  0.80 
Visual Scale        0.74 

HRQ-Melasma allows a score ranging from zero to 76. When compared to DLQI-BRA categories, projection of the scores permits their scaling thus: <15 (not affected); 16-35 (slightly affected); 36-50 (moderately affected); 51-65 (very affected); >65 (extremely affected).22

The dimensional structure of HRQ-Melasma, evaluated by confirmatory factor analysis, was based on the performance of the following indicators: chi-square by degrees of freedom ratio (CMIN/DF) = 1.77 (p<0.01), adjusted goodness-of-fit index (AGFI) = 0.84, comparative fit index (CFI) = 0.96; and root mean square error of approximation (RMSEA) = 0.06. Performance of the indicators showed adequate fit to the latent dimensional structure: AGFI≥0.9; CFI≥0.9; RMSEA≤0.8; and CMIN/DF<5.23,24

A retest of HRQ-Melasma was performed in 42 individuals with a mean interval of 9.5 ± 2.6 days. High temporal stability was demonstrated by intraclass correlation coefficient of the 2 measurements: 0.91 (p<0.01).

HRQ-QoL was completed by the subjects in less than 10 minutes.


A new multidimensional structured questionnaire was developed and validated to evaluate QoL in patients with facial melasma, following the classical steps of psychometry.37 The focus groups revealed different aspects of daily life in which the condition affects QoL.

The study sample was representative not only of Brazilian melasma patients as a whole (mainly childbearing-age women38,39), but also for development of the psychometric instrument, since it evaluated individuals with heterogeneous socioeconomic levels and age, gender, and clinical extent of the disease.

HRQ-Melasma was constructed by reducing 49 items to 19, distributed in 4 broad dimensions which allowed the comprehension of the phenomenon in different domains of impact on QoL. The instrument displayed good internal consistency, as well as in its dimensions, and the item-reducing process did not introduce psychometric bias (rho > 0.95). The idealized dimensional structure was post-ratified by confirmatory factor analysis.

The Physical/Appearance dimension consisted of items that reflected aspects of the disease concerning aesthetic impact, pronounced aging, and differences in appearance relative to a group.

The Social/Professional dimension consisted of items that reflected the impact of the disease in relation to professional competitiveness, limitations in socializing, leisure, and building personal relations.

Feelings such as disappointment, embarrassment, sadness, depression, other people’s perceptions of oneself, and harm to self-image and personal acceptance caused by the disease comprised the Psychological dimension, with the largest number (7) of items in HRQ-Melasma.

The Treatment dimension included only 3 items and showed low informativity according to Rasch analysis. However, it was an independent dimension that explored important aspects of the disease: intervention tolerability and lesion recurrence despite treatment.

HRQ-Melasma also correlated highly with the visual scale of inconvenience, DLQI-BRA, and MELASQoL-PB. The weak correlation of HRQ-Melasma and MELASQoL-PB with MASI showed that the impact of melasma transcends the Physical dimension.40 Likewise, test-retest stability was high, altogether lowing its use in clinical practice and research.

The study’s main limitation was its single-center design. The psychometric and structural properties of HRQ-Melasma should be explored in other cultural and linguistic settings with analytical tools adjusted to the measures’ statistical characteristics in order to identify the construct’s strengths and weaknesses for investigating quality of life in melasma.


We developed a specific multidimensional instrument to assess QoL in melasma, with suitable psychometric performance.

Financial support: None.

Conflict of interest: None.

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Work conducted at the Department of Dermatology and Radiotherapy, Faculdade de Medicina, Universidade Estadual Paulista (FMB-Unesp), Botucatu (SP), Brazil.

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Anais Brasileiros de Dermatologia

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