Journal Information
Vol. 98. Issue 2.
Pages 159-167 (1 March 2023)
Vol. 98. Issue 2.
Pages 159-167 (1 March 2023)
Original Article
Open Access
Comedogenic lupus: a rare variant of chronic cutaneous lupus erythematosus – case series
Lucas Campos Garciaa,b, Isabela Boechat Moratoa,
Corresponding author

Corresponding author.
, Raquel Ferreira Queiroz de Meloa, Everton Carlos Siviero do Valea
a Dermatology Service, Hospital das Clínicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil
b Department of Internal Medicine, Faculty of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil
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Comedogenic lupus is an uncommon variant of cutaneous lupus, clinically characterized by the presence of comedones, papules and erythematous-infiltrated plaques, cysts and scars in photo-exposed areas, mimicking acne vulgaris and acneiform eruptions.


To report clinicopathological characteristics of patients with comedogenic lupus in a tertiary dermatology service over a 15-year period and review cases described in the literature.


Retrospective study of patients with clinical and histopathological diagnoses of comedogenic lupus between the years 2006 and 2021. The literature search was carried out in the PubMed and VHL Regional Portal databases, using the terms: “comedogenic lupus” and “acneiform lupus” in Portuguese and English.


Five patients were diagnosed during the described period, all female, with a mean age of 56.6 years. Smoking was observed in three cases, as well as pruritus. The most affected site was the face, especially the pre-auricular, malar and chin regions. Follicular plugs, epidermal thinning and liquefaction degeneration of the basal layer were predominant histopathological findings. Hydroxychloroquine was used as the first-line treatment; however, other medications were used, such as dapsone, methotrexate, tretinoin cream, and topical corticosteroids. The literature search identified 17 cases, with a mean age of 38.9 years, 82% of which were women. Only 23% had a diagnosis of systemic lupus erythematosus. Hydroxychloroquine was the most recommended systemic medication.

Study limitations

Retrospective, single-center study. The literature search was carried out in two databases.


Dermatologists should be aware of acneiform conditions with poor response to the usual treatment. Early diagnosis and treatment reduce the risk of unaesthetic scars.

Acneiform eruptions
Case reports
Lupus erythematosus, cutaneous
Lupus erythematosus, discoid
Lupus erythematosus, systemic
Full Text

Chronic cutaneous lupus erythematosus (CCLE) has more than twenty described clinical variants.1 Some of these variants, such as discoid lupus erythematosus (DLE), the most common chronic subtype, exhibit striking clinical features that contribute to diagnostic suspicion. Other variants, however, such as comedogenic lupus (CL), can pose a diagnostic challenge.1 CL is a rare form of CCLE,1 which is clinically characterized by multiple erythematous papules, comedones, cysts, and acneiform scars in sun-exposed areas, which may be associated with typical DLE lesions.2 Although uncommon, CL should be considered in the differential diagnosis of acne vulgaris and acneiform eruptions refractory to conventional treatment.1 The present study reports five cases of CL and compares their demographic data, clinical characteristics and treatment with those of the 17 published cases, in addition to illustrating the different types of skin lesions and discussing the main histopathological findings.


This is a single-center, retrospective study carried out at the Dermatology Service of Hospital das Clínicas, Universidade Federal de Minas Gerais. Data from patients diagnosed with CL in the last 15 years, between 2006 and 2021, were collected. The literature search was carried out using PubMed and VHL (Virtual Health Library) Regional Portal databases using the terms “comedonal lupus” and “acneiform lupus” in Portuguese and English. Ten articles were retrieved by this search, while another six were identified from the bibliographic references.


During the study period, from 2006 to 2021, five cases diagnosed as CL were identified, which are described below. The literature search identified 17 cases of the comedogenic variant. The main clinical and demographic characteristics of the cases in this series and those reported in the literature are described in Table 13–16 and the histopathological findings of the five cases in this series are listed in Table 2.Case 1

A 45-year-old female patient, non-smoker, had been undergoing treatment for acne vulgaris for years, with unsatisfactory response. On examination, she had erythematous papules, open comedones, and cysts on the submandibular, chin and supralabial regions (Fig. 1). She had had a diagnosis of DLE 18 years ago, with dyschromic atrophic plaques on the face and scalp. A biopsy of the area with cysts and comedones was performed and the histopathological findings confirmed the diagnosis of CL (Table 2). Methotrexate 15 mg/week, dapsone 100 mg/day, and betamethasone dipropionate ointment were prescribed and surgical excision of the cystic lesions was performed, with some punctate scars remaining. She did not meet clinical or laboratory criteria for systemic lupus erythematosus (SLE).

Figure 1.

Open comedones and acneiform scars on the supralabial, mentum and preauricular regions after treatment.

Case 2

An 85-year-old female patient, non-smoker, presented open comedones on erythematous, infiltrated, and pruritic plaques on the mandibular, malar and cervical regions for the last year (Fig. 2). The scalp showed extensive areas of alopecia with dyschromia, scaling, and follicular keratosis. The anatomopathological examination of a malar region skin specimen was compatible with CL (Table 2). She had a history of pericardial effusion, undergoing etiological investigation. The subsequent laboratory examination showed proteinuria, reduced glomerular filtration rate, presence of urinary cell casts, complement consumption, antinuclear antibody (ANA) 1:640, with a coarse speckled nuclear pattern, and SLE was diagnosed. After three months of treatment with hydroxychloroquine 400 mg/day, systemic corticosteroid therapy, and photoprotection, there was partial improvement of the acneiform lesions, resolution of pruritus and control of the systemic disease activity.

Figure 2.

(A–B) Infiltrated erythematous plaques, containing open comedones, on the malar, mandibular and cervical regions.

Case 3

A 41-year-old female patient, smoker, presented with infiltrated erythematous plaques for two years, containing open comedones, punctate scars and cysts in the auricular, paranasal, and malar regions (Fig. 3). She reported pruritus and pain. The anatomopathological examination was compatible with CL (Table 2). She also had erythematous-dyschromic discoid plaques on the arms, clinically compatible with DLE. In the subsequent laboratory examination, she had ANA 1: 160, with a dense fine speckled nuclear pattern, without any other criteria for SLE. Systemic therapy was implemented with hydroxychloroquine 400 mg/day, methotrexate 15 mg/week and intralesional corticosteroids, with partial improvement of the lesions after eight months.

Figure 3.

Erythematous and hyperchromic plaque with comedones on the paranasal, malar, supraorbital (A) and auricular (B) regions.

Case 4

A 50-year-old female patient, hypertensive and a smoker, diagnosed with DLE for three years, was treated with chloroquine diphosphate 250 mg/day. She developed multiple open and closed comedones on previous DLE plaques on the nasal, pre-auricular, malar and mentum regions (Fig. 4). The anatomopathological examination of the preauricular lesion was compatible with CL (Fig. 5 and Table 2). ANA was negative, without clinical and laboratory criteria for SLE. During the follow-up, 15 mg/day of methotrexate was added to the treatment, in addition to tretinoin cream 0.025% and benzoyl peroxide 5%. After one year of follow-up, chloroquine diphosphate was replaced by dapsone 100 mg/day, due to bilateral macules, but the patient did not tolerate the medication. There was a partial improvement after the introduction of doxycycline 200 mg/day.

Figure 4.

Open and closed comedones over active discoid lupus erythematosus plaques; (A) Distribution of plaques on the face; (B) Detail of the lesion.

Figure 5.

(A) Histological section showing hyperkeratosis, epidermal thinning, liquefaction degeneration of the basal layer and large follicular plug; in the dermis, superficial and deep periadnexal and perivascular mononuclear infiltrate (Hematoxylin & eosin, ×40). (B) Detail of the follicular plug obstructing a dilated hair follicle. Note the liquefaction degeneration of the follicular wall and adjacent epidermis (Hematoxylin & eosin, ×100).

Case 5

A 62-year-old female patient, smoker, diagnosed with DLE for fifteen years, had plaques with open and closed comedones on the mentum, preauricular and auricle regions (Fig. 6). The anatomopathological examination of the preauricular lesion was compatible with CL (Table 2). ANA was negative, without clinical and laboratory criteria for SLE. She has received betamethasone dipropionate and tretinoin cream 0.025%, with good control.

Figure 6.

(A) Comedones and depressed scar over erythematous plaque on the mentum. (B) Preauricular discoid lupus erythematosus plaque and open comedones on the auricular region.


Table 1.

Main clinical and demographic characteristics of the cases in the present series and of the 17 series published in the literature.

Case  Year of Publication  Age  Sex  Smoker  Time of evolution  Pruritus  Sites  ANA  SLE  DLE  Prior diagnosis of acne  Treatment  Evolution 
Case 1    45  No  18 years  No  Face (submandibular, mentum, supralabial)  Negative  No  Yes  Yes  Methotrexate 15 mg/week, dapsone 100 mg/day, betamethasone dipropionate ointment, surgical excision (cysts)  Improvement 
Case 2    85  No  1 year  Yes  Face (mandibular, malar) and cervical regions  1:640 CSN  Yes  Yes  No  Hydroxychloroquine 400 mg/day, systemic corticosteroid therapy, photoprotection  Partial improvement 
Case 3    41  Yes  2 years  Yes  Face (paranasal, maxillae) and auricle  1:160 FSN  No  Yes  No  Hydroxychloroquine 400 mg/day, methotrexate 15 mg/week, intralesional corticosteroid, photoprotection  Partial improvement 
Case 4    50  Yes  2 years  Yes  Face (nasal, pre-auricular, malar, mentum)  Negative  No  Yes  No  Methotrexate 15 mg/week, dapsone 100 mg/day, tretinoin cream 0.025%, benzoyl peroxide 5%, doxycycline 200 mg/day  Partial improvement 
Case 5    62  Yes  15 years  No  Face (mentum, pre-auricular) and auricular region  Negative  No  Yes  No  Topical corticosteroids, tretinoin cream 0.025%  Improvement 
Haroon et al.3  1972  32  No  4 years  Yes  Back  Negative  No  Yes  No  Not informed  Not reported 
Motel et al.4  1995  24  No  Not informed  No  Face and cervical region  1:5120 Nucleolar  Yes  No  Yes  Erythromycin 250 mg QID  No improvement 
Motel et al.4  1995  29  No  7 years  Yes  Face and upper trunk  1:2560 HN  Yes  No  Yes  Tetracycline and erythromycin  No improvement 
Chang et al.5  2006  32  No  3 years  No  Face (nasolabial fold)  Negative  No  Yes  No  Not reported  Not reported 
El Sayed et al.6  2007  60  No  8 years  Yes  Face (malar)  1:80 FSN  No  No  No  Hydroxychloroquine 400 mg/day, photoprotection, topical clobetasol and tazarotene  Improvement 
Stavrakoglou et al.2  2008  38  No  7 years  Yes  Face, back and anterior thorax  Negative  No  No  Yes  Hydroxychloroquine 400 mg/day, photoprotection  Complete improvement in 1 year 
Hemmati et al.7  2009  33  No  1,5 years  No  Scalp  Not informed  No  Yes  Yes  Hydroxychloroquine 400 mg/day, photoprotection, triamcinolone infiltration, manual extraction  Improvement 
Farias et al.8  2011  35  No  2 years  Yes  Face (nasal dorsum, mentum) and ears  Not informed  No  Yes  Yes  Hydroxychloroquine 400 mg/day, tetracycline, photoprotection  Improvement in 6 months 
Ugarte et al.9  2014  41  ‒  11 years  No  Face, pre-auricular and scalp regions  1:320a  No  No  ‒  Hydroxychloroquine 400 mg/day and prednisone 20 mg/day  Remission 
Deruelle-Khazaal et al.10  2017  32  No  2 years  Yes  Face (mentum) and ear  Positiveb  No  Yes  Yes  Prednisone and chloroquine diphosphate  Pruritus improvement 
Vieira et al.11  2018  32  No  2 years  Yes  Face (mentum)  Negative  No  Yes  Yes  Prednisone and chloroquine diphosphate  Improvement in 3 months 
Mohanty et al.12  2019  20  No  8 months  No  Face, cervical, dorsum and abdomen  Positiveb  Yes  No  Yes  Methotrexate 15 mg/week, and hydroxychloroquine 200 mg/day  Not reported 
Droesch et al.1  2019  57  No  1 year  No  Face (malar, mentum, forehead) and cervical regions  1:80 speckled nuclear  No  Yes  Yes  Hydroxychloroquine 200 mg/day  Lost to follow-up 
Zhou et al.13  2019  54  No  2 years  No  Scalp  Negative  No  Yes  Yes  Oral hydroxychloroquine and topical isotretinoin 0.01%  Reduction of comedones in 3 months 
Cozzani et al.14  2020  45  No  1 year  Yes  Ears  Negative  No  Yes  No  Photoprotection  Stability 
Gaitibi et al.15  2021  50  ‒  1 year  No  Scalp  Negative  No  No  No  Not reported  Not reported 
Chessé et al.16  2021  48  ‒  2 months  ‒  Mentum  Positivea  Yes  Yes  No  Minocycline 100 mg and topical tretinoin  Good response 

ANA, antinuclear antibody; HN, homogeneous nuclear pattern; FSN, fine speckled nuclear pattern; CSN, coarse speckled nuclear pattern; SLE, systemic lupus erythematosus; DLE, discoid lupus erythematosus; F, female; M, male.


Pattern not informed.


Pattern and title not informed.

Table 2.

Histopathological findings observed in the cases of the present series.

Histopathological findings  Case 1  Case 2  Case 3  Case 4  Case 5 
Orthokeratosis  –  –  – 
Epidermal thinning  – 
Liquefaction degeneration  –  – 
Lymphocytic infiltrate 
Pigment incontinence  –  –  –  – 
Follicular plug 
Mucin deposition  –  –  – 
Thickening of the basement membrane  –  – 

CL is a rare presentation of CCLE, with only 17 cases described in the literature, to the best of the authors’ knowledge, and the present study has added five new cases. According to the literature, it predominates in women between the third and fourth decades of life, with a mean age of 38.9 years, different from the mean age of the cases in the present study, which was 56.6 years. Smoking, as in other forms of the disease, seems to be an important risk factor.

The pathogenesis of LC has not been well established yet. Follicular plugs, common in DLE, were observed in all cases in this series, as well as the presence of hyperkeratosis and inflammatory infiltrate near the pilosebaceous unit. These three findings, taken together, could justify its clinical expression with comedones, papules, and acneiform scars.1,5,13

The clinical manifestations include comedones, erythematous papules, and punctate scars affecting sun-exposed areas.1 The patients in this series had lesions on the face and on the auricular region. The presence of concomitant lesions of classic DLE, in addition to the confluence of lesions into infiltrated plaques, perilesional erythema, and telangiectasias, may be helpful in differentiating CL from other acneiform eruptions.5,9 Pruritus is frequently described in the literature and was present in three of the five described patients.1,2 Two patients developed inflammatory cysts. All patients had DLE lesions, concomitantly. The screening for antinuclear antibodies was positive in two cases, but only one of the patients was diagnosed with SLE.

Although the occurrence of acneiform lesions in areas that are photo-exposed and refractory to conventional treatment for acne may suggest CL, histopathology is crucial for the diagnosis.1,11 The histological findings are similar to those seen in DLE, including hyperkeratosis, epidermal thinning, liquefaction degeneration of the basal layer, thickening of the basement membrane, pigment incontinence and predominantly lymphocytic inflammatory infiltrate in the papillary and periadnexal dermis; however, dilated follicular ostia, epidermal cysts, and prominent follicular plugs are patent in CL.7,13 Of these classic findings, follicular plugs were the most prevalent, observed in all cases. The presence of mucin was observed in two cases, a finding not reported in previously published reports, but which is also seen in other subtypes of CCLE, especially in lupus tumidus. The increase in the number of cases of comedogenic lupus described may identify the true prevalence of this variant.

Differential diagnoses include acne vulgaris, comedogenic nevus, and nodular cutaneous elastoidosis with cysts and comedones (Favre-Racouchot disease).5,13 As described in the literature, three cases had been previously diagnosed and treated as acne vulgaris, without success.

The treatment of this form of CCLE can be challenging, and photoprotection is essential in all cases, as recommended in the other variants. Topical therapy with retinoids such as tretinoin and tazarotene and the use of topical and/or intralesional corticosteroids may contribute to improvement, as seen in Case 5. However, most cases require systemic therapy,7,8 with hydroxychloroquine (HCQ) being considered the first line of treatment.3 Two patients in this series had a partial response to methotrexate associated with HCQ. Only two patients showed complete symptom improvement, one after using methotrexate associated with dapsone (Case 1) and the other with topical corticosteroid associated with topical tretinoin (Case 5). Dapsone, successfully used in one of the cases in this series, even though its use has not been previously reported in CL, could have a potential role in the treatment, although further studies are needed.


The present study contributes to the world literature by providing five new cases and intends to increase the understanding of this unusual and an understudied variant of CCLE. Due to its rarity and little knowledge of CL by dermatologists, the diagnosis can be delayed, with a negative impact on quality of life, since it is a dermatosis with the potential for significant unaesthetic complications, as also observed in classic DLE.1 CL should be included in the differential diagnosis of acneiform conditions in conjunction with atypical manifestations and poor response to the usual treatment.9 An early diagnosis and treatment could alleviate the morbidity and reduce the risk of scarring.1

Financial support

None declared.

Authors' contributions

Lucas Campos Garcia: Design and planning of the study; data collection; drafting and editing of the manuscript and critical review of relevant intellectual content; approval of the final version of the manuscript.

Isabela Boechat Morato: Design and planning of the study; data collection; drafting and editing of the manuscript; critical review of the intellectual content; approval of the final version of the manuscript.

Raquel Ferreira Queiroz de Melo: Drafting and editing of the manuscript and data collection; approval of the final version of the manuscript.

Everton Carlos Siviero do Vale: Design and planning of the study; drafting and editing of the manuscript and critical review of relevant intellectual content; approval of the final version of the manuscript.

Conflicts of interest

None declared.

C. Droesch, C. Magro.
A comedonal variant of chronic cutaneous lupus erythematosus: case report and literature review.
JAAD Case Rep., 5 (2019), pp. 801-805
A. Stavrakoglou, J. Hughes, I. Coutts.
A case of discoid lupus erythematosus masquerading as acne.
Acta Derm Venereol., 88 (2008), pp. 175-176
T.S. Haroon, K.A. Fleming.
An unusual presentation of discoid lupus erythematosus.
Br J Dermatol., 87 (1972), pp. 642-645
P.J. Motel, E.F. Bernstein, M. Fazio, H. Humeniuk, Y.C. Kauh.
Systemic lupus erythematosus in patients diagnosed with treatment-resistant acne.
Int J Dermatol., 34 (1995), pp. 338-340
Y.H. Chang, S.H. Wang, C.C. Chi.
Discoid lupus erythematosus presenting as acneiform pitting scars.
Int J Dermatol., 45 (2006), pp. 944-945
F. El Sayed, R. Dhaybi, A. Ammoury, J. Bazex.
Lupus comédonien [Lupus comedonicus].
Ann Dermatol Venereol., 134 (2007), pp. 897-898
I. Hemmati, N. Otberg, M. Martinka, A. Alzolibani, I. Restrepo, J. Shapiro.
Discoid lupus erythematosus presenting with cysts, comedones, and cicatricial alopecia on the scalp.
J Am Acad Dermatol., 60 (2009), pp. 1070-1072
D.F. Farias, R.M. Gondim, I.P. Redighieri, H. Muller, V. Petri.
Comedonic lupus: a rare presentation of discoid lupus erythematosus.
An Bras Dermatol., 86 (2011), pp. S89-91
C. Ugarte, F. Cheng, M. Anodal, C. Marcucci, G. Hidalgo, G. Sánchez, et al.
Lupus discoide: patrón de cicatrización acneiforme. A propósito de un caso.
Arch Argent Dermatol., 64 (2014), pp. 114-116
R. Deruelle-Khazaal, M. Ségard, A.C. Cottencin-Charrière, I. Carotte-Lefebvre, P. Thomas.
Lésions acnéiformes révélatrices d’un lupus érythémateux chronique [Chronic lupus erythematosus presenting as acneiform lesions].
Ann Dermatol Venereol., 129 (2002), pp. 883-885
M.L. Vieira, E.R.M.C. Marques, Y.L.A. Leda, L.F. Noriega, D.L. Bet, G.A.A.M. Pereira.
Chronic cutaneous lupus erythematosus presenting as atypical acneiform and comedonal plaque: case report and literature review.
Lupus., 27 (2018), pp. 853-857
B. Mohanty, B. Kumar.
Systemic lupus erythematosus camouflaging: As refractory acne in a young girl.
J Family Med Prim Care., 8 (2019), pp. 276-279
M.Y. Zhou, C. Tan.
Comedonic discoid lupus erythematous.
Scand J Rheumatol., 48 (2019), pp. 331-332
E. Cozzani, A. Herzum, M. Burlando, A. Parodi.
Comedonal variant of chronic cutaneous lupus erythematosus causing mutilation of the earlobe.
JAAD Case Rep., 6 (2020), pp. 843-844
F.A. El Gaitibi, J. Belcadi, S.O. Ali, K. Znati, K. Senouci, N. Ismaili.
Comedonal plaque on the scalp.
JAAD Case Rep., 11 (2021), pp. 90-92
C. Chessé, M. Fernández-Tapia, F. Borzotta.
Lupus comedónico: presentación inusual de lupus cutáneo.
Actas Dermosifiliogr., 112 (2020), pp. 370-371

Study conducted at the Dermatology Service, Hospital das Clínicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.

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